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Cell Signaling: principles and mechanisms, by Wendell Lim, Bruce Mayer, Tony Pawson
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Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.
- Sales Rank: #499844 in eBooks
- Published on: 2014-06-16
- Released on: 2014-06-16
- Format: Kindle eBook
Review
The authors pull off the difficult trick of providing both an effective introduction to the basics of cellular signal transduction and a comprehensible and remarkably comprehensive description of the details of specific signaling systems. Cell Signaling focuses solidly on biochemical and biophysical principles of signal transduction, but the work is so accessible and complete that it will provide even upper-level undergraduate students a solid basis for further studies in systems biology. The clarity of the graphic presentations combined with the clarity of the text means that this book will be a well-used tool by any owner, ranging from undergraduate to seasoned researcher.-- CHOICE
About the Author
Wendell Lim is at the University of California, San Francisco, where he is Professor of Cellular and Molecular Pharmacology. The principal focus of his research is the structure and mechanism of protein interaction domains and the logic by which these components are used to build complex cellular signaling systems.
Bruce Mayer is at the University of Connecticut Health Center, where he is a Professor of Genetics and Developmental Biology. Current work in his group focuses on characterizing and manipulating tyrosine kinase-mediated signal transduction pathways.
Anthony Pawson, deceased, was Senior Investigator and Director of Research in the Department of Medical Genetics and Microbiology at the University of Toronto where his research focused on the molecular dissection and functional significance of protein-protein interactions in signal transduction.
Most helpful customer reviews
2 of 2 people found the following review helpful.
OK text
By William LAmoreaux
Cell Signaling is an average textbook for upper division undergraduates or beginning graduate students. The book lays a solid foundation in the first few chapters, which deal with the biochemical aspects of protein-protein interactions. By the time the student reaches Chapters 3 on, the information is at the same time repetitive and new. For example, Chapter 3 deals with protein kinases and phosphatases, which is then covered again in chapter 4, which introduces new protein modifications. The information in chapters 3 and 4 lead to a nice discussion on subcellular localization of signaling proteins, with some redundance (reinforcement?) built in. Chapter 6 introduces lipids involved in cell signaling before talking about the membrane lipids in Chapter 7 (for the authors: I would recommend putting the information in 7 before that in 6).
I think the authors try to simplify the concepts of molecular switches using terms like Writer, Eraser and Reader, which my senior undergrads don't seem to appreciate. There are some editing changes that need to be made in the text and the online resources from Garland need a really serious editor (Chapter 6: Small Signaling Medicators instead of Mediators!).
I developed the course and chose the text, but I will be considering other options that have better organization and editing.
0 of 0 people found the following review helpful.
Fantastic textbook
By A reader
The best book on cell signaling (Signal transduction) out there. It cuts through the complexity of molecular pathways by focusing on principles and the modular nature of molecular interactions, while providing deep chemical and evolutionary explanations for why such systems work that way. Rather than feeling overwhelmed by the sheer amount of detailed information, as in many textbooks on signaling, one comes out with a structured vision of pathways, and a much better understanding of the unifying principles guiding molecular recognition, interaction and assembly. At the same time, it provides detailed information on specific pathways important for development, cancer, immunity etc...Really an amazing book, highly recommended...
0 of 0 people found the following review helpful.
Most biology books I read are kinda boring; they just list a bunch of facts which ...
By goldentime
Most biology books I read are kinda boring; they just list a bunch of facts which I can hardly remember after reading them. This book, however, is perfect. The arguments are very clear.
Reading the book makes me feel better about biology, especially when I feel a lot things I do in research don't make much sense.
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